Pharmacology and Pharmacokinetics of the Antiviral Agent -D-2 ,3 -Dideoxy-3 -Oxa-5-Fluorocytidine in Cells and Rhesus Monkeys†
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چکیده
10.1128/AAC.49.7.2589-2597.2005. 2005, 49(7):2589. DOI: Antimicrob. Agents Chemother. Raymond F. Schinazi Harold M. McClure, Chung K. Chu, Dennis C. Liotta and Thierry Beltran, Shuli Mao, Selwyn J. Hurwitz, Jason Grier, Brenda I. Hernandez-Santiago, Huachun Chen, Ghazia Asif, Monkeys -Oxa-5-Fluorocytidine in Cells and Rhesus ′ -Dideoxy-3 ′ ,3 ′ -d-2 β Antiviral Agent Pharmacology and Pharmacokinetics of the
منابع مشابه
Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys.
Beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine (D-FDOC) is an effective inhibitor of human immunodeficiency virus 1 (HIV-1) and HIV-2, simian immunodeficiency virus, and hepatitis B virus (HBV) in vitro. The purpose of this study was to evaluate the intracellular metabolism of d-FDOC in human hepatoma (HepG2), human T-cell lymphoma (CEM), and primary human peripheral blood mononuclear (PBM) cells...
متن کاملPharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys.
2',3'-Dideoxy-5-fluoro-3'-thiacytidine (FTC) is a nucleoside analog that selectively inhibits human immunodeficiency and hepatitis B viruses in vitro. In this study, the preclinical pharmacokinetics of racemic FTC in rhesus monkeys following intravenous and oral administration were characterized. The terminal half-life of FTC was independent of the route of administration and averaged 1.34 +/- ...
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The discovery of a novel cytosine nucleoside, â-D-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine (D-D4FC), as a potent antihuman immunodeficiency virus (HIV) agent led us to synthesize a series of analogues and derivatives of â-D-D4FC that could be more selective and also possess increased glycosidic bond stability. The synthesized D-D4FC analogues were evaluated for antiHIV-1 activity, antican...
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Objective(s): In the present study the effect of stress on monkeys that had learned to retrieve food from a five-chamber receptacle, as well as the relationship between their behavior and the serum cortisol and epinephrine levels and relative size of the amygdala was evaluated. Materials and Methods: Six male rhesus monkeys were individually given access to the food reward orderly. They could e...
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Deoxycytidylate deaminase, catalyzing the conversion of dCMP to dUMP, is an important enzyme in the de novo synthesis of thymidine nucleotides. It also may be involved in the action, as well as the metabolism of anticancer agents. Recently, several L- and D-configuration pyrimidine deoxynucleoside analogs were found to be potent antiviral and antitumor agents. Their interaction with dCMP deamin...
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تاریخ انتشار 2005